1,2-Di(oxiranyl)ethylene glycol
VAL-083
CAS: 23261-20-3
Molecular Formula: C6H10O4
1,2-Di(oxiranyl)ethylene glycol - Names and Identifiers
| Name | VAL-083 |
| Synonyms | VAL-083 NSC-132313 Dulcitol diepoxide Dianhydrodulcitolum Dianhydrogalactitol 1,2,5,6-DIANHYDRODULCITOL 1,2-Di(oxiranyl)ethylene glycol |
| CAS | 23261-20-3 |
1,2-Di(oxiranyl)ethylene glycol - Physico-chemical Properties
| Molecular Formula | C6H10O4 |
| Molar Mass | 146.14 |
| Density | 1.567 |
| Melting Point | 96.5-98.5 °C |
| Boling Point | 185.74°C (rough estimate) |
| pKa | 13.53±0.20(Predicted) |
| Storage Condition | -20℃ |
| Refractive Index | 1.4310 (estimate) |
| In vitro study | VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h. VAL-083 (5 μM) inhibits the growth of SF188 by ∼95%. VAL-083 inhibits T98G cells growth in a dose-dependent manner (IC 50 <5 μM). VAL-083 (Dianhydrogalactitol) inhibits the proliferation of HUVEC and U251 cells at doses of more than 12.5 μg/mL. VAL-083 (3.125, 6.25, 12.5 μg/mL) also suppresses the migration and invasion, and reduces MMP2, VEGF, VEGFR2, and FGF2 expression in HUVEC and U251 cells. VAL-083 (1,2:5,6-dianhydrogalactitol, 1, 2, 5 μM) dose-dependently induces cell cycle arrest at G2/M phase in the 3 glioma cell lines. VAL-083 activates two parallel signaling cascades, the p53-p21 and the CDC25C-CDK1 cascade. In addition, VAL-083 significantly enhances the radiosensitivity of LN229 cells. |
| In vivo study | VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. VAL-083 (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl. |
1,2-Di(oxiranyl)ethylene glycol - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.843 ml | 34.214 ml | 68.428 ml |
| 5 mM | 1.369 ml | 6.843 ml | 13.686 ml |
| 10 mM | 0.684 ml | 3.421 ml | 6.843 ml |
| 5 mM | 0.137 ml | 0.684 ml | 1.369 ml |
Last Update：2024-01-02 23:10:35
1,2-Di(oxiranyl)ethylene glycol - Reference Information
| biological activity | VAL-083 is an alkylator that produces N7 methylation on DNA, has anti-tumor activity. |
| Target | DNA Alkylator |
Last Update：2024-04-09 21:54:55
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